Osteoblasts develop differentiate from mesenchymal cells or embryonic connective tissue cells and are responsible for osteogenesis by getting deposited onto bones like dermal layers thus providing the basis for new bone substance, i.e. bone matrix. In this process, they tend to undergo change to a framework of osteocytes which are no longer divisible, with that framework being gradually mineralised and filled up with calcium. Osteoclasts are antagonists to osteoblasts.
